Our Employment Philosophy

Because the quality of Otonomy’s employees is the key to our success, we carefully select each new employee. We are committed to developing products that will benefit people’s lives and build value for our shareholders. As a team, we value honesty and integrity, knowledge, initiative and leadership, and a commitment to quality and improvement in everything we do. We want our decisions and actions to demonstrate these values. We treat one another with respect and take pride in the significant contributions that come from teamwork and the diversity of our organization.  We strive for excellence and sound, responsible decision making. We know that Otonomy’s success depends on the performance of each member of our team.

When filling open positions, we will always strive to select the most qualified candidate regardless of race, color, religion, sex, national origin, ancestry, age, medical condition, sexual orientation, marital status, pregnancy, physical or mental disability, veteran or other protected status. We are proud to be an Equal Opportunity Employer with commitment to Affirmative Action for Minorities, Women, Individuals with Disabilities and Veterans.

Current Openings


Sr. Research Associate/Associate Scientist, Research and Development

The functions of the Senior Research Associate/Associate Scientist include investigating therapeutic targets and candidate molecules in cochlea cells and tissue using molecular, biochemical, and optical techniques to support the growth of Otonomy’s pipeline. This scientist will have expertise in signaling and regulatory pathways, pharmacology, or neuroscience, and possess strong scientific and laboratory skills. Prior experience with otic tissues is not required, though experience with primary cell culture is essential, including harvesting primary neurons or working with sensitive cell lines (e.g., stem cells). This scientist must be teamwork-oriented and will be an integral member of our research team, focused on developing new assays, evaluating candidate compounds, and identifying new targets for treating hearing disorders, as well as contributing to building a pipeline of therapeutics for other otic indications.

  • Develop and execute in vitro and ex vivo biochemical, molecular, and cell-based assays in support of applied drug discovery and development. Support efforts to evaluate candidate drugs in animal models, in close collaboration with the Preclinical Group.
  • Develop and validate testing models to assess drug-able pathways of human ear disease to evaluate the efficacy of small molecule and biopharmaceutical drug candidates. Facilitate selection of relevant ear diseases for preclinical and clinical evaluation.
  • Provide technical excellence that ensures Otonomy is at the cutting edge of cellular biology.
  • Actively contribute to project teams and provide clear and consistent communication of ideas, data, conclusions and outcomes.
  • Contribute to manuscripts for key publications (abstracts, posters, presentations) consistent with the overall scientific and medical communications plan. Present data and findings internally and externally as requested. Support the development of data and other materials for patents and regulatory documentation.
  • May perform other related duties as required and/or assigned.

This position is located in San Diego.

Qualified applicants will have the following:

  • BS/BA or advanced degree in Biology, Molecular Biology, Cell Biology, Pharmacology, Neuroscience, or related discipline.
  • Senior Research Associate: BS/BA plus 5 years of experience or MS/MA plus 3 years of experience within a biotechnology or relevant academic role.
  • Associate Scientist: PhD, or MS/MA plus 5 years of experience within a biotechnology or relevant academic role.
  • Comprehensive knowledge of current practices in cell and molecular biology and pharmacology research, especially within Neuroscience, Ophthalmology, or Otology.
  • Expertise in primary cell culture, assay development, automation of assays, and state-of-the-art molecular and biochemical techniques.
  • Experience in developing testing models for drug target characterization and validation, and translating new biology into viable therapeutics.
  • A commitment to high-quality research and the execution of research plans in a timely and organized manner.
  • Excellent verbal and written communication skills, as well as strong interpersonal skills, including the ability to interact effectively with collaborators, clients, vendors and personnel, who may have different levels of technical knowledge and understanding.

Sr. Research Associate, In Vivo

Conduct and analyze in vivo experiments and report findings.   Submit recommendation and design of new experiments and approaches.

Conduct and assist scientist in designing and analyzing in-vivo experiments in a multi-species vivarium.

Conduct animal dosing, tissue sampling and various surgical techniques.

Conduct Mammalian cell culture and microscopy.

Produce data and graphs to support scientific findings.  Draft technical reports, quantitative analyses, and other on-going documentation of assigned projects.  Maintain current laboratory notebooks and/or computer files and assist in administering safety policies and procedures.

Present data to supervisor and at internal meetings as requested.  May present data at external meetings.

Participate in the development of data utilized in the completion of research grants and/or patent applications.

Maintain a functional knowledge of the theories and techniques of an experienced Sr. Research Associate in the In Vivo Pharmacology field and share knowledge with peers and others.

May perform other related duties as required and/or assigned. May train and mentor junior staff.

All qualified applicants will have the following:

  • BS in Biology or equivalent
  • 3 years’ experience working with multi-species of animals in a vivarium environment
  • Hands-on experience with animal surgical techniques, as well as dosing and tissue sampling
  • Basic Histology experience a plus
  • Experience with in-vivo efficacy assessments and in-vivo toxicity required
  • Experience with microscopy a plus
  • Basic experience with Mammalian cell culture required

Regulatory and QA

Quality Assurance Manager (GCP)

The position of Quality Assurance Manager-GCP Compliance will lead and direct QA activities in the areas of GCP auditing, training, establishment and implementation of quality standards to support Otonomy’s research, development and commercial organization. This position is a member of Otonomy’s Quality and Regulatory Affairs Department and reports directly to the Sr. Director, QA. This position can be located in either our San Diego or Alamo, CA office.  The QA Manager-GCP Compliance works with the Clinical, Regulatory, Technical Operations (supply chain), and other departments to provide QA oversight and management to ensure GCP compliance.  Represents QA team for interactions with Contract Research Organizations (CROs) and provides input into requirements of GCP quality matters and industry regulatory standards. Assists in regulatory agency GCP inspections at Otonomy and leading GCP audits at clinical sites and contract service providers. Provides direction and guidance on the implementation and management of Otonomy’s quality and compliance program to domestic and international GCP guidelines and regulations, and company policies.  Responsible for defining and meeting functional area goals and objectives as they relate to departmental goals.

This role will develop GCP-related standard operating procedures (SOPs) in compliance with FDA and ICH guidelines. Establish a GCP training program including Otonomy’s quality standards and compliance, keeping current with the GCP regulatory landscape. Provide ongoing GCP training, expectations, GCP issues, and support to Otonomy’s Clinical Department. Provide compliance assessments for trial master files (TMFs) clinical protocols, case report forms (CRFs), data collection, clinical study reports (CSRs) and other clinical documents, as required. Review and approve audit reports and Corrective and Preventive Actions (CAPAs). Provide compliance assessment, metrics, and updates to senior quality, regulatory and clinical management. Participate in the preparation of Quality Agreements/Contracts with CRO Management/Service providers, as applicable. Assist with creating/implementing GCP inspection systems and coordinating follow-up actions and responses to resolving inspection findings. Provide input into the GCP supplier/vendor qualification program, including arranging audits, drafting, audit reports, closing out audits and updating of the approved suppliers list. Manage the development and refinement of Otonomy GCP quality systems and procedures.

Qualified applicants will have the following:

  • Bachelors’ degree in a scientific discipline or the equivalent education and experience.
  • 5+ years of relevant experience in the pharmaceutical or biotech industry.
  • Working experience in a Quality environment with expertise in GCP.
  • Additional experience with Good Laboratory Practices a plus.
  • Comprehensive knowledge of GCP regulations.
  • Experience with documentation systems, document review and auditing responsibilities.
  • Must have background working in an interdisciplinary team environment.
  • Strong verbal and written communication skills and detail orientation required.
  • Must be proactive, independent, hard-working and committed to achieving difficult goals.



Pharmaceutical Development

Associate Scientist/Scientist, Pharmaceutical Development

This role will develop phase appropriate analytical methods for drugs in complex formulation matrix/drug delivery system to support Otonomy’s drug development programs. Conduct, analyze, and report on experiments to support analytical method evaluation, method transfer, study investigations as well as pre-formulation, formulation, and process development in pharmaceutical development. May need to support the oversight of analytical development, method validation, and product testing at CROs and internal drug product specifications. Support pre-clinical and clinical development efforts by conducting laboratory studies relating to product characterization, stability, and quality. Perform formulation stability studies. Write analytical test methods, protocols and reports as part of analytical transfers to CRO/CMO for GMP and non-GMP testing and make sure they are consistently implemented by the vendors. Maintain proper documentation of all experimental procedures and results. Present data at internal and external meetings. Maintain a thorough knowledge of the applicable scientific arena and routinely educate peers and others on that information. Participate in the development of data and materials for use in research grants and/or patent applications, as well as regulatory filings. May perform other related duties as required and/or assigned.

This position is located in our San Diego office.

Qualified applicants will have the following:

  • Associate Scientist: Minimum of B.S. degree in Analytical Chemistry, Pharmaceutical Sciences, Chemical Engineering or related discipline is required
  • Scientist: MS or PhD degree in Analytical Chemistry, Pharmaceutical Sciences is required
  • Analytical Method development experience is required.
  • At least five (5) years of method development experience with a B.S. degree; three (3) years’ method development experience with an M.S. degree, one year (1) method development experience with a PhD degree, preferably in an industrial setting.
  • Solid knowledge and hands on experience in various analytical techniques such as HPLC, USP dissolution testing apparatus, UV-Vis, as well as instrumentation such as particle sizers, Osmometers, Viscometers, etc.
  • Ability to manage and execute on multiple and competing priorities is expected.
  • Solid communication skills and the ability to work as a team member are essential.
  • Great attention to details and strong ability to cope with change.




Senior Accountant/Manager

This role performs a variety of finance and accounting activities including the preparation of clinical trial accruals and contract accruals. Works closely with the Clinical group to prepare clinical trial accruals. Performs contract accrual tracking and accounting. Reviews new contracts for any accounting implications and accruals. Prepares and inputs general journal entries and monthly journal entries related to areas of responsibility as required, including monthly stock compensation journal entries. Prepares account reconciliations and supporting schedules for balance sheet accounts related to areas of responsibility including support for all estimates. Provides support and prepares financial information requested by external auditors during their quarterly reviews and annual audit. Assists finance management in daily duties including addressing inquiries, researching accounting issues and interfacing with other departments; implements finance policies and procedures. Performs various ad-hoc projects or reports as required or requested by management. Ensures that accounting functions are performed in accordance with US GAAP, SOX requirements and SEC guidelines.

Qualified applicants will have the following:

  • Bachelor’s degree in Business Administration, or other related discipline, or the equivalent knowledge and experience is required. Professional certification in Accounting preferred.
  • Requires 3+ years’ relevant experience
  • Big 4 or National CPA experience preferred
  • CPA preferred
  • Proficiency in MS Excel and Word; and experience with Great Plains desirable
  • Must have excellent customer service attitude
  • Publicly-traded company experience preferred
  • Experience with Sarbanes-Oxley compliance requirements preferred
  • Strong, current working knowledge of GAAP and project accounting
  •  Ability to collect, analyze and interpret data to produce accurate reporting
  • Proven ability to thrive in a team environment, being willing to assist other team members to achieve team goals and objectives, and go the extra mile when necessary
  • Ability to develop, recommend and implement procedures; excellent analytical, problem solving and organizational skills
  • Effective verbal and written communication skills, and ability to effectively interact with employees in a team-base environment




Regional Account Director

The Market Access National/Regional Account Director will primarily lead the development and management of key account relationships across assigned Regional Payers, and regional Medicare Administrative Carriers (MAC), Integrated Delivery Networks (IDN) and may also lead the development and management of key account relationships across select Accountable Care Organizations (ACO), Fee For Service Medicaid plans (FFS),  and other assigned corporate accounts across the managed markets customer channels for Otonomy’s line of products.

The territory covered by this role will generally include the following states, but may be revised from time to time, subject to business needs: Illinois, Indiana, Iowa, Kansas, Minnesota, Missouri, Nebraska, Wisconsin, Idaho, Oklahoma.

Essential Functions:

Maintains and manages relationships with assigned key managed markets customer groups including,  Regional Payers State  Medicaid plans Managed Medicaid plans, and regional MAC’s, and other corporate accounts as assigned, which may include IDN, ACO’s.

Develops product access strategies and tactics for specific managed markets customer segments and payer channels in support of launch plans for Otonomy’s pipeline products.

Leads the development of account level plans of action for assigned payers and managed markets customers, designed to ensure optimal access for Otonomy products

Profiles key payer segments and assigned accounts to assess applicable formulary coverage policies, utilization controls, formulary review practices and timelines, geographic coverage areas, level of regional and national influence, and other attributes relevant to optimal patient access for Otonomy products

Leads the development and negotiation of payer contracts, as applicable, across all assigned accounts for Otonomy products

Effectively communicates product coverage status for all assigned accounts across Sales and Marketing                                                                                         

Effectively supports Sales and Marketing by providing expert and compliant consultation to the Otonomy Sales Force, HEOR and Medical team and other functional teams on specific payer                   

coverage policies and formulary status, as well as how payers evaluate and make decisions on relevant therapeutic areas

Support RBM’s and field sales in management of large IDN strategies and pull through efforts

Identify demonstration Projects between Payer/ Provider’s /Otonomy

Support FRM team where necessary and provide Regional Payer support

Compliantly engages all internal and external stakeholders to optimally support product access

Identifies competitive threats and develops response strategies to ensure optimal payer access for Otology products

The role is remote and requires travel in excess of 50%.

May perform other related duties as required and/or assigned


Bachelors Degree in business or comparable education and experience is required.  Advanced degree in business is preferred.


Requires a minimum of 10 years total commercial experience with a minimum 5 years’ experience in a comparable Managed Markets National/Regional Accounts position including development of access strategies and tactical plans supporting specialty drugs or other relevant experience.  Recent Hospital and Surgery Center product launch experience preferred.  Advanced knowledge of Medicare Part B and D, as well as commercial payer coverage practices, trends, utilization controls, formulary review processes necessary.  In addition, advanced knowledge of Health Care Reform legislation relevant to pharmaceutical product access required.  Advanced knowledge of Medicaid and Managed Medicaid, as well as Medicaid expansion through the Affordable Care Act important.  Proven track record for establishing and improving product coverage across Medicare Part B and D, as well as Commercial payers required. Advanced contract negotiation, analytical, and business skills needed.  Previous team management and sales experience preferred.  Must be able to travel up to 60% of time.

Location: Field Based with regular travel to Otonomy offices in San Diego, CA and targets.


To Apply

Please send your resume with salary requirements to or mail to
6275 Nancy Ridge Drive, Suite 100, San Diego, CA 92121, attention Human Resources.

Otonomy is an Equal Opportunity Employer