We are passionate about coupling our deep understanding of the neuroscience of the ear with our drug delivery and development expertise to advance a broad product pipeline to address significant unmet needs in neurotology.
Ménière's disease is a chronic condition characterized by episodic vertigo attacks, fluctuating hearing loss that becomes permanent over time, tinnitus, and a feeling of ear fullness. OTIVIDEX is a sustained-exposure formulation of the steroid dexamethasone for patients with Ménière’s disease that has completed one successful Phase 3 clinical trial. An additional Phase 3 trial to support a submission for registration is ongoing.
OTO-313 is a sustained-exposure formulation of gacyclidine, a potent and selective NMDA receptor antagonist, in development for the treatment of tinnitus. A Phase 1/2 trial, evaluating safety and exploratory efficacy measures of OTO-313 is ongoing.
OTO-413 is a sustained-exposure formulation of brain-derived neurotrophic factor (BDNF) which is a naturally occurring protein involved in neuron growth and repair. Nonclinical studies have demonstrated that local administration of BDNF repairs neuronal synapses damaged due to noise trauma or exposure to ototoxic chemicals and restores hearing function. A Phase 1/2 clinical trial for OTO-413 in patients with speech-in-noise-hearing difficulty is ongoing.
OTO-510 is a sustained-exposure formulation of an undisclosed small molecule designed for intratympanic administration to provide protection against cisplatin-induced hearing loss (CIHL), without tumor protection.
OTO-6XX induces hair cell regeneration and is being developed for the treatment of severe hearing loss. Otonomy has selected a lead compound for development.
Otonomy has established a strategic corporate collaboration to develop a gene therapy treatment targeting mutations in the gap junction beta 2 gene (GJB2) - the most common cause of congenital hearing loss.
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